Protective efficacy of Toxoplasma gondii GRA12 or GRA7 recombinant proteins encapsulated in PLGA nanoparticles against acute Toxoplasma gondii infection in mice

BackgroundToxoplasma gondii is an apicomplexan parasite that affects the health of humans and livestock, and an effective vaccine is urgently required.Nanoparticles can modulate and improve cellular and humoral immune responses.MethodsIn the current study, poly (D, L-lactic-co-glycolic acid) (PLGA) nanoparticles were used as a delivery system for t

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The impact of self-compassionate mindfulness on online learning behavioral engagement of international students during COVID-19: Positive emotion and self-improvement motivation as mediators

Focusing on the domain of self-compassion, this study explored the promotion mechanism of online learning behavioral engagement (OLBE) of international students in China under COVID-19.Positive emotion and self-improvement motivation were selected as Throw mediators.Participants were 606 international students from 8 countries who were studying onl

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Autoimmune Encephalitis versus Creutzfeldt-Jakob disease in a patient with typical Facio-brachial dystonic seizures: A case report with Diagnostic challenges

Background: Diagnosis of rapidly progressive dementia (RPD) is very challenging.There are many conditions that fall into category of RPD ranging from autoimmune causes to neurodegenerative causes.Autoimmune encephalitis should be readily diagnosed and treated because of its response to immunomodulators.However there is no treatment available for co

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